General Clinical Chemistry Analyzers and Accessories
Abcam LY2886721, BACE-1 inhibitor, 25MG
MW 390.4 Da, Purity >98%. Potent and selective BACE-1 inhibitor (IC₅₀ = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC₅₀ of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC₅₀ values are 18.5 nM and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC₅₀ ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen R-BAIBA
Chemical. CAS 2140-95-6. Formula C4H9NO2. MW 103.12. Synthetic Beta-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine. beta-Aminoisobutyric acid occurs in two isomeric forms and both enantiomers of beta-Aminoisobutyric acid can be detected in human urine and plasma. In plasma, the S-enantiomer is the predominant type due to active renal reabsorption. In contrast, urine almost exclusively contains the R-enantiomer of beta-Aminoisobutyric acid, which is eliminated both by filtration and tubular secretion. The S-enantiomer of beta-Aminoisobutyric acid is predominantly derived from the catabolism of valine, the R-enantiomer is the product of the catabolism of the pyrimidine bases uracil and thymine by the enzyme dihydropyrimidine dehydrogenase DPD, in what constitutes the first step of the pyrimidine degradation pathway.
Abcam Ganetespib (STA-9090), 25MG
MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC₅₀ of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC₅₀ of 43 nM.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Cyclotrisiloxanol pentamethyl
Chemical. CAS 106916-50-1. Formula C5H16O4Si3. MW 224.43. Organosilicon compounds are organometallic compounds containing carbon-silicon bonds. Organosilicon compounds are widely encountered in commercial products. Most common are antifoamers, caulks sealant, adhesives, and coatings made from silicones. Other important uses include agricultural and plant control adjuvants commonly used in conjunction with herbicides and fungicides. Several organosilicon compounds have been investigated as pharmaceuticals.
AdipoGen N4-Acetylsulfadimethoxine
Chemical. CAS 555-25-9. Formula C14H16N4O5S. MW 352.37. Synthetic Metabolite of the long-acting sulfonamide antibiotic sulfadimethoxine, used in freshwater aquaculture. Sulfonamide that is benzenesulfonamide substituted by an acetylamino group at position 4 and a 4,6-dimethoxy-pyrimidin-2-yl group at the nitrogen atom. Compound can be used as analytical reference material.
Abcam E7820, 5MG
MW 336.4 Da, Purity >=98%. A small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Inhibition of integrin alpha 2 leads to an inhibition of cell-cell interactions, endothelial cell-matrix interactions, vascular endothelial cell proliferation and angiogenesis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GW-311616A, 1MG
MW 434 Da, Purity >=98%. A potent and selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC₅₀ values of 22 nM for HNE, >100 μM for trypsin, cathepsin G and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Coumaphos
Chemical. CAS 56-72-4. Formula C14H16ClO5PS. MW 362.77. Synthetic. An organophosphate pesticide. Acetylcholinesterase AChE inhibitor in the nervous system with subsequent accumulation of toxic levels of acetylcholine ACh. Selective insecticide used for control of a wide variety of livestock insects, including cattle grubs, screw-worms, lice, scabies, flies and ticks. Also used against ectoparasites, which are insects that live on the outside of host animals such as sheep, goats, horses, pigs and poultry. Not used on agricultural or residential plants.
Abcam Alvespimycin (17-DMAG) hydrochloride, 10MG
MW 653.2 Da, Purity >99%. A potent Hsp90 inhibitor (IC₅₀ = 62 nM), can bind to the ATP-binding motif and inhibit the protein chaperoning activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 4'-hydro x yazobenzene-2-carbo x ylic acid (HABA), 5G
MW 242.23 Da. An endogenous metabolite. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CK869, Actin-related protein 2/3 (Arp2/3) comple x inhibitor, 10MG
MW 394.3 Da, Purity >98%. Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC₅₀ = 11 μM) and inhibits the formation of actin filament comet tails by Listeriamonocytogenes in infected SKOV3 cells (IC₅₀ = 7 μM) . Does not inhibit budding or fission yeast Arp2/3 complexes.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist, 100MG
MW 485.5 Da. Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC₅₀ = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SP-2509, LSD1 inhibitor, 25MG
MW 437.9 Da, Purity >98%. Potent, selective (IC₅₀ = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A). No activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Daclatasvir (BMS-790052), HCV NS5A protein inhibitor, 25MG
MW 738.9 Da, Purity =97%. Daclatasvir a potent, direct acting, small molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC₅₀ values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also inhibits infection by the JFH-1 genotype 2a virus in cultured cells. Daclatasvir is thought to inhibit relication of the HCV viral genome by affecting the subcellular localization of HCV NS5A and preventing its incorporation into relication complexes. In HCV-infected Huh7 cells, Daclatasvir (1 nM) inhibits viral RNA synthesis and viron assembly. Daclatasvir displays moderate activity against the OAT1B1 (IC₅₀ = 1.5 μM) and OAT1B3 (IC₅₀ = 3.27 μM) organic anion transporters.
The product is subject to the following: Abcam Restricted Use Statement
Hach Company CLF10sc Free CL Analyzer w/pH
CLF10sc Free Chlorine Analyzer (Panel Only) with Combination pH SensorIncludes CL10 sc Panel-1 m digital extension cable-Panel Manual-Combination pH Sensor Manual-Chlorine Sensor Manual
